What happens when an inherited piece of genetic code predicts the exact cancers that took your family members — not as an active diagnosis, but as a ticking probability map?

In this episode of Changed By Cancer, Dr. Randi Paynter sits down with author Tiffany Graham Charkosky (Living Proof: How Love Defied Genetic Legacy). Tiffany has never had cancer, but her life has been shaped by it. After losing her mother at age 30, her grandfather in his 50s, and her uncle at 41, an astute researcher hel

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A quick check-in and an exciting request for your input! After a stubborn back injury kept me away from the microphone last week, I am resting up off-camera and planning our next slate of standalone Epi Edit deep dives.

These standalone episodes are our space to pull back the curtain on the science, population data, and systemic healthcare policies that shape cancer care. But before hitting record on the next round,

When someone receives a cancer diagnosis, the impact is never confined to the individual patient. It sends an immediate shockwave through an entire family, transforming spouses, partners, parents, and children overnight into primary advocates, home clinicians, and logistical anchors.




In this episode of Changed By Cancer, host Dr. Randi Paynter sits down with Charlotte Bayala, host of The Cancer Caregiver and Caregiver Breathing Room. For nearly fourteen years, Charlotte has walked beside h

"So to me, the chemo was a healing experience. I felt good from it." — Marissa


In Part One, Marissa described a decade-long path through progressive Multiple Sclerosis and an aggressive Stage III breast cancer diagnosis that arrived, paradoxically, as a second chance at life. In Part Two, host Dr. Randi Paynter continues the conversation as Marissa begins the chemotherapy regimen designed to treat her cancer — and instead finds that it starts undoing years of neurological damage.




Mariss

"When I got diagnosed with breast cancer, all of a sudden I realized I could die. And then I felt terrible about how little I thought of my life and realized that I actually had a wonderful life... Being alive meant I could see my family, read a book, go outside. I could not believe how much I didn't see that I had all along." — Marissa


In 2012, Marissa was a 42-year-old mother living in South Florida when she experienced a severe, sudden, and inexplicable major depressive episode. It would t

"Every day that I wake up and I don't have a new tumor, I'm adding to the survivorship data. So you have to live with a certain amount of uncertainty... I would like to curl up at night with a whole sheaf of data that doesn't exist yet, because I'm the one who's helping to create it." — Deborah

When we evaluate health metrics on a macro scale, we often treat long-term oncology survivorship as a finished equation — a simple box checked after a patient rings a bell. But the actual infrastructure

In April of 2013, Deborah was a busy mother of two young boys living in Brooklyn when a spot on her back came back positive for malignant melanoma. A sentinel lymph node biopsy was clear, but the pathology noted "melanoma in transit" — malignant cells already on their way to other parts of her body.

By September of 2014, the "bad stuff" had landed in her lungs. Her oncologist recommended a clinical trial combining a short course of radiation with a novel immunotherapy drug named Ipilimumab (Yer

When we are thrown into a health crisis, our brains desperately search for certainty through anchors, maps, timelines, and data. In the United States, the absolute gold standard for tracking population-level oncology data is a public health system called SEER (Surveillance, Epidemiology, and End Results) managed by the National Cancer Institute.

In this episode of The Epi Edit, cancer epidemiologist Dr. Randi Paynter pulls back the curtain on how SEER works under the hood, analyzing its 50-year

When we talk about cancer, we often talk about it in isolation — as a private medical crisis. But cancer doesn't happen in a vacuum. It happens to people who live in specific communities, navigate specific systems, and face distinct structural realities.

In this inaugural episode of The Epi Edit, host Dr. Randi Paynter steps behind the mic for a solo session to outline the mission of this new format and dismantle a deeply flawed framework that has dominated public health for decades: the patien

Aiona came to California from Tonga when she was about a year old. She grew up in Sacramento, went on an LDS mission at twenty-one, came home, fell in love on what was essentially a second date, and eventually landed in Petaluma, CA — managing a Hampton Inn, raising two daughters, and working twelve-hour days until the day she noticed something had changed in her breast.

That was November 2025. The biopsy confirmed it: Stage III, hormone receptor-positive, HER2-negative breast cancer — eleven c